Low-Level Persistence of Drug Resistance Mutations in Hepatitis B Virus-Infected Subjects with a Past History of Lamivudine Treatment

We sought to determine the prevalence of hepatitis B virus (HBV) lamivudine (LAM)-resistant minority variants in subjects who once received LAM but had discontinued it prior to virus sampling. We performed direct PCR Sanger sequencing and ultradeep pyrosequencing (UDPS) of HBV reverse transcriptase...

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Detalhes bibliográficos
Main Authors: Margeridon-Thermet, Severine, Svarovskaia, Evguenia S., Babrzadeh, Farbod, Martin, Ross, Liu, Tommy F., Pacold, Mary, Reuman, Elizabeth C., Holmes, Susan P., Borroto-Esoda, Katyna, Shafer, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535911/
https://ncbi.nlm.nih.gov/pubmed/23114756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01601-12
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