In Vitro Combination of Amdoxovir and the Inosine Monophosphate Dehydrogenase Inhibitors Mycophenolic Acid and Ribavirin Demonstrates Potent Activity against Wild-Type and Drug-Resistant Variants of Human Immunodeficiency Virus Type 1

Amdoxovir [(−)-β-d-2,6-diaminopurine dioxolane (DAPD)] is a nucleoside analogue reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) replication. DAPD is deaminated by adenosine deaminase to the guanosine analogue dioxolane guanosine (DXG), which is subsequently phosphoryla...

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Detalhes bibliográficos
Main Authors: Borroto-Esoda, Katyna, Myrick, Florence, Feng, Joy, Jeffrey, Jerry, Furman, Phillip
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC525453/
https://ncbi.nlm.nih.gov/pubmed/15504868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4387-4394.2004
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