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Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells

Progression through the various stages of skin tumorigenesis is correlated with an altered expression of the integrin α3β1, suggesting that it plays an important role in the tumorigenic process. Using epidermis-specific Itga3 KO mice subjected to the 7,12-dimethylbenzanthracene (DMBA)/12-O-tetradeca...

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Main Authors: Sachs, Norman, Secades, Pablo, van Hulst, Laura, Kreft, Maaike, Song, Ji-Ying, Sonnenberg, Arnoud
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535625/
https://ncbi.nlm.nih.gov/pubmed/23236172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204614110
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