Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium

Age-associated decline in immunity to infection has been documented across multiple pathogens, yet the relative contributions of the aged priming environment and of lymphocyte-intrinsic defects remain unclear. To address the impact of the aging environment on T-cell priming, adult naïve OT-I TCR tra...

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Autores principales: Li, Gang, Smithey, Megan J, Rudd, Brian D, Nikolich-Žugich, Janko
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2012
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533767/
https://ncbi.nlm.nih.gov/pubmed/22862959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2012.00867.x
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