Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

Mixed-lineage leukemia 4 (MLL4; also called MLL2 and ALR) enzymatically generates trimethylated histone H3 Lys 4 (H3K4me3), a hallmark of gene activation. However, how MLL4-deposited H3K4me3 interplays with other histone marks in epigenetic processes remains largely unknown. Here, we show that MLL4...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Dhar, Shilpa S., Lee, Sung-Hun, Kan, Pu-Yeh, Voigt, Philipp, Ma, Li, Shi, Xiaobing, Reinberg, Danny, Lee, Min Gyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2012
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533079/
https://ncbi.nlm.nih.gov/pubmed/23249737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.203356.112
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi