Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

Mixed-lineage leukemia 4 (MLL4; also called MLL2 and ALR) enzymatically generates trimethylated histone H3 Lys 4 (H3K4me3), a hallmark of gene activation. However, how MLL4-deposited H3K4me3 interplays with other histone marks in epigenetic processes remains largely unknown. Here, we show that MLL4...

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Detalhes bibliográficos
Main Authors: Dhar, Shilpa S., Lee, Sung-Hun, Kan, Pu-Yeh, Voigt, Philipp, Ma, Li, Shi, Xiaobing, Reinberg, Danny, Lee, Min Gyu
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533079/
https://ncbi.nlm.nih.gov/pubmed/23249737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.203356.112
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