Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4

MLL3 and MLL4 are two closely related members of the SET1/MLL family of histone H3K4 methyltransferases and are responsible for monomethylating histone H3K4 on enhancers, which are essential in regulating cell-type-specific gene expression. Mutations of MLL3 or MLL4 have been reported in different t...

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Vydáno v:Nat Commun
Hlavní autoři: Liu, Yanli, Qin, Su, Chen, Tsai-Yu, Lei, Ming, Dhar, Shilpa S., Ho, Jolene Caifeng, Dong, Aiping, Loppnau, Peter, Li, Yanjun, Lee, Min Gyu, Min, Jinrong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318328/
https://ncbi.nlm.nih.gov/pubmed/30604749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07906-3
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