Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF

Histone methyltransferase MLL4 is centrally involved in transcriptional regulation and is often mutated in human diseases, including cancer and developmental disorders. MLL4 contains a catalytic SET domain that mono-methylates histone H3K4 and seven PHD fingers of unclear function. Here, we identify...

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Publicado no:Nat Commun
Main Authors: Zhang, Yi, Jang, Younghoon, Lee, Ji-Eun, Ahn, JaeWoo, Xu, Longxia, Holden, Michael R., Cornett, Evan M., Krajewski, Krzysztof, Klein, Brianna J., Wang, Shu-Ping, Dou, Yali, Roeder, Robert G., Strahl, Brian D., Rothbart, Scott B., Shi, Xiaobing, Ge, Kai, Kutateladze, Tatiana G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534582/
https://ncbi.nlm.nih.gov/pubmed/31127101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10324-8
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