Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A

Nonstructural protein 5B (NS5B) is essential for hepatitis C virus (HCV) replication as it carries the viral RNA-dependent RNA polymerase enzymatic activity. HCV replication occurs in a membrane-associated multiprotein complex in which HCV NS5A and host cyclophilin A (CypA) have been shown to be pre...

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Detalles Bibliográficos
Main Authors: Rosnoblet, Claire, Fritzinger, Bernd, Legrand, Dominique, Launay, Hélène, Wieruszeski, Jean-Michel, Lippens, Guy, Hanoulle, Xavier
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531740/
https://ncbi.nlm.nih.gov/pubmed/23152499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.392209
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