Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance

Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the role for adipose tissues mitochondria in the development of these disorders is currently unknown. To understand the impact of adipose tissue mitochondria on whole body metabolism, we have generated a...

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Hauptverfasser: Vernochet, Cecile, Mourier, Arnaud, Bezy, Olivier, Macotela, Yazmin, Boucher, Jeremie, Rardin, Matthew J., An, Ding, Lee, Kevin Y., Ilkayeva, Olga R., Zingaretti, Cristina M., Emanuelli, Brice, Smyth, Graham, Cinti, Saverio, Newgard, Christopher B., Gibson, Bradford W., Larsson, Nils-Göran, Kahn, C. Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529641/
https://ncbi.nlm.nih.gov/pubmed/23168219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.10.016
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