Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance

Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the role for adipose tissues mitochondria in the development of these disorders is currently unknown. To understand the impact of adipose tissue mitochondria on whole body metabolism, we have generated a...

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Main Authors: Vernochet, Cecile, Mourier, Arnaud, Bezy, Olivier, Macotela, Yazmin, Boucher, Jeremie, Rardin, Matthew J., An, Ding, Lee, Kevin Y., Ilkayeva, Olga R., Zingaretti, Cristina M., Emanuelli, Brice, Smyth, Graham, Cinti, Saverio, Newgard, Christopher B., Gibson, Bradford W., Larsson, Nils-Göran, Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529641/
https://ncbi.nlm.nih.gov/pubmed/23168219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.10.016
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