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A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis
Insulin and insulin-like growth factor 1 (IGF-1) act as anti-apoptotic hormones. We found that, unexpectedly, double knockout (DKO) cells that lacked both insulin and IGF-1 receptors (IR and IGF1R, respectively), were resistant to apoptosis induced through either the intrinsic or extrinsic pathway....
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4364396/ https://ncbi.nlm.nih.gov/pubmed/21139139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001173 |
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