Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate

Recent studies have identified a number of transcriptional regulators, including E2A, early B-cell factor 1 (EBF1), FOXO1, and paired box gene 5 (PAX5), that promote early B-cell development. However, how this ensemble of regulators mechanistically promotes B-cell fate remains poorly understood. Her...

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Detalhes bibliográficos
Main Authors: Mansson, Robert, Welinder, Eva, Åhsberg, Josefine, Lin, Yin C., Benner, Christopher, Glass, Christopher K., Lucas, Joseph S., Sigvardsson, Mikael, Murre, Cornelis
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529039/
https://ncbi.nlm.nih.gov/pubmed/23213261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211427109
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