A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates the B cell fate

It is now established that the transcription factors E2A, EBF1 and Foxo1 play critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1 as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regul...

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Hlavní autoři: Lin, Yin C, Jhunjhunwala, Suchit, Benner, Christopher, Heinz, Sven, Welinder, Eva, Mansson, Robert, Sigvardsson, Mikael, Hagman, James, Espinoza, Celso A, Dutkowski, Janusz, Ideker, Trey, Glass, Christopher K, Murre, Cornelis
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896911/
https://ncbi.nlm.nih.gov/pubmed/20543837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1891
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