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Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors
To investigate how transcription factor levels impact B-lymphocyte development, we generated mice carrying transheterozygous mutations in the Pax5 and Ebf1 genes. Whereas combined reduction of Pax5 and Ebf1 had minimal impact on the development of the earliest CD19(+) progenitors, these cells displa...
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| Publicado no: | J Exp Med |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4493409/ https://ncbi.nlm.nih.gov/pubmed/26056231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132100 |
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