Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency

Early B-cell factor 1 (Ebf1) is a transcription factor with documented dose-dependent functions in normal and malignant B-lymphocyte development. To understand more about the roles of Ebf1 in malignant transformation, we investigated the impact of reduced functional Ebf1 dosage on mouse B-cell proge...

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Veröffentlicht in:Blood
Hauptverfasser: Prasad, Mahadesh A. J., Ungerbäck, Jonas, Åhsberg, Josefine, Somasundaram, Rajesh, Strid, Tobias, Larsson, Malin, Månsson, Robert, De Paepe, Ayla, Lilljebjörn, Henrik, Fioretos, Thoas, Hagman, James, Sigvardsson, Mikael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2015
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481594/
https://ncbi.nlm.nih.gov/pubmed/25838350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-617282
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