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Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations
Multidrug resistance in Gram-negative bacteria, to which multidrug efflux pumps such as the AcrB transporter makes a major contribution, is becoming a major public health problem. Unfortunately only a few compounds have been cocrystallized with AcrB, and thus computational approaches are essential i...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528587/ https://ncbi.nlm.nih.gov/pubmed/23175790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218348109 |
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