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Presenilin transgenic mice as models of Alzheimer’s disease

Mutations in presenilin-1 (PS1) and presenilin-2 (PS2) cause familial Alzheimer’s disease (FAD). Presenilins influence multiple molecular pathways and are best known for their role in the γ-secretase cleavage of type I transmembrane proteins including the amyloid precursor protein (APP). PS1 and PS2...

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Detaylı Bibliyografya
Asıl Yazarlar: Elder, Gregory A., Sosa, Miguel A. Gama, De Gasperi, Rita, Dickstein, Dara L., Hof, Patrick R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527905/
https://ncbi.nlm.nih.gov/pubmed/19921519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00429-009-0227-3
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