Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

BACKGROUND: Mutations in presenilin-1 (Psen1) cause familial Alzheimer's disease (FAD). Both hypoxia and ischemia have been implicated in the pathological cascade that leads to amyloid deposition in AD. Here we investigated whether Psen1 might regulate hypoxic responses by modulating induction...

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Detaylı Bibliyografya
Asıl Yazarlar: De Gasperi, Rita, Sosa, Miguel A Gama, Dracheva, Stella, Elder, Gregory A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955646/
https://ncbi.nlm.nih.gov/pubmed/20863403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-38
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