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Presenilin transgenic mice as models of Alzheimer’s disease
Mutations in presenilin-1 (PS1) and presenilin-2 (PS2) cause familial Alzheimer’s disease (FAD). Presenilins influence multiple molecular pathways and are best known for their role in the γ-secretase cleavage of type I transmembrane proteins including the amyloid precursor protein (APP). PS1 and PS2...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527905/ https://ncbi.nlm.nih.gov/pubmed/19921519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00429-009-0227-3 |
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