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Selective Expression of Presenilin 1 in Neural Progenitor Cells Rescues the Cerebral Hemorrhages and Cortical Lamination Defects in Presenilin 1-Null Mutant Mice
Mice with a null mutation of the presenilin 1 gene (Psen1(-/-))die during late intrauterine life or shortly after birth and exhibit multiple CNS and non-CNS abnormalities, including cerebral hemorrhages and altered cortical development. The cellular and molecular basis for the developmental effects...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1698506/ https://ncbi.nlm.nih.gov/pubmed/16079160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.01946 |
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