Selective Expression of Presenilin 1 in Neural Progenitor Cells Rescues the Cerebral Hemorrhages and Cortical Lamination Defects in Presenilin 1-Null Mutant Mice

Mice with a null mutation of the presenilin 1 gene (Psen1(-/-))die during late intrauterine life or shortly after birth and exhibit multiple CNS and non-CNS abnormalities, including cerebral hemorrhages and altered cortical development. The cellular and molecular basis for the developmental effects...

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Main Authors: Wen, Paul H., Gasperi, Rita De, Sosa, Miguel A. Gama, Rocher, Anne B., Friedrich, Victor L., Hof, Patrick R., Elder, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698506/
https://ncbi.nlm.nih.gov/pubmed/16079160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.01946
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