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Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (−)-cocaine
It can be argued that an ideal anti-cocaine medication would be one that accelerates cocaine metabolism producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway, i.e. hydrolysis catalyzed by butyrylcholinesterase (BChE) in plasma. However, wild-type...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527670/ https://ncbi.nlm.nih.gov/pubmed/22917637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2012.08.003 |
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