A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Numerous genetic and epigenetic alterations render cancer cells selectively dependent on specific genes and regulatory pathways, and represent potential vulnerabilities that can be therapeutically exploited. Here we describe an RNA interference (RNAi)–based synthetic interaction screen to identify g...

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Detaylı Bibliyografya
Asıl Yazarlar: Xie, Li, Gazin, Claude, Park, Sung Mi, Zhu, Lihua J., Debily, Marie-anne, Kittler, Ellen L. W., Zapp, Maria L., Lapointe, David, Gobeil, Stephane, Virbasius, Ching-Man, Green, Michael R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527276/
https://ncbi.nlm.nih.gov/pubmed/23284306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003151
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