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Epigenetic Silencing of the RASSF1A Tumor Suppressor Gene through HOXB3-Mediated Induction of DNMT3B Expression
SUMMARY: The RASSF1A tumor suppressor gene is epigenetically silenced in a variety of cancers. Here we perform a genome-wide human shRNA screen and find that epigenetic silencing of RASSF1A requires the homeobox protein HOXB3. We show that HOXB3 binds to the DNA methyltransferase DNMT3B gene and inc...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776651/ https://ncbi.nlm.nih.gov/pubmed/19854132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.10.009 |
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