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Epigenetic Silencing of the RASSF1A Tumor Suppressor Gene through HOXB3-Mediated Induction of DNMT3B Expression
SUMMARY: The RASSF1A tumor suppressor gene is epigenetically silenced in a variety of cancers. Here we perform a genome-wide human shRNA screen and find that epigenetic silencing of RASSF1A requires the homeobox protein HOXB3. We show that HOXB3 binds to the DNA methyltransferase DNMT3B gene and inc...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776651/ https://ncbi.nlm.nih.gov/pubmed/19854132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.10.009 |
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