Epigenetic Silencing of the RASSF1A Tumor Suppressor Gene through HOXB3-Mediated Induction of DNMT3B Expression

SUMMARY: The RASSF1A tumor suppressor gene is epigenetically silenced in a variety of cancers. Here we perform a genome-wide human shRNA screen and find that epigenetic silencing of RASSF1A requires the homeobox protein HOXB3. We show that HOXB3 binds to the DNA methyltransferase DNMT3B gene and inc...

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Main Authors: Palakurthy, Rajendra Kumar, Wajapeyee, Narendra, Santra, Manas K., Gazin, Claude, Lin, Ling, Gobeil, Stephane, Green, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776651/
https://ncbi.nlm.nih.gov/pubmed/19854132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.10.009
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