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Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors
We previously identified 28 cofactors through which a RAS oncoprotein directs transcriptional silencing of Fas and other tumor suppressor genes (TSGs). Here we performed RNAi-based epistasis experiments and found that RAS-directed silencing occurs through a highly ordered pathway that is initiated b...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3814642/ https://ncbi.nlm.nih.gov/pubmed/24105743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.227413.113 |
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