Identification of Epigenetic Regulators of DUX4-fl for Targeted Therapy of Facioscapulohumeral Muscular Dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic de-repression of the disease locus, leading to pathogenic misexpression of the DUX4 gene in skeletal muscle. While the factors and pathways involved in normal repression of the FSHD locus in healthy cells have been well characteri...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Himeda, Charis L., Jones, Takako I., Virbasius, Ching-Man, Zhu, Lihua Julie, Green, Michael R., Jones, Peter L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035737/
https://ncbi.nlm.nih.gov/pubmed/29759937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.04.019
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