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A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy
The Double homeobox 4 (DUX4) gene is an important regulator of early human development and its aberrant expression is causal for facioscapulohumeral muscular dystrophy (FSHD). The DUX4-full length (DUX4-fl) mRNA splice isoform encodes a transcriptional activator; however, DUX4 and its unique DNA bin...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5802938/ https://ncbi.nlm.nih.gov/pubmed/29415061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192657 |
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