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Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD)

Facioscapulohumeral muscular dystrophy (FSHD) is typically an adult onset dominant myopathy. Epigenetic changes in the chromosome 4q35 region linked to both forms of FSHD lead to a relaxation of repression and increased somatic expression of DUX4-fl (DUX4-full length), the pathogenic alternative spl...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jones, Takako I., Parilla, Megan, Jones, Peter L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778869/
https://ncbi.nlm.nih.gov/pubmed/26942723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150938
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