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Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD)

Facioscapulohumeral muscular dystrophy (FSHD) is typically an adult onset dominant myopathy. Epigenetic changes in the chromosome 4q35 region linked to both forms of FSHD lead to a relaxation of repression and increased somatic expression of DUX4-fl (DUX4-full length), the pathogenic alternative spl...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Jones, Takako I., Parilla, Megan, Jones, Peter L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778869/
https://ncbi.nlm.nih.gov/pubmed/26942723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150938
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