A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Numerous genetic and epigenetic alterations render cancer cells selectively dependent on specific genes and regulatory pathways, and represent potential vulnerabilities that can be therapeutically exploited. Here we describe an RNA interference (RNAi)–based synthetic interaction screen to identify g...

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Detalhes bibliográficos
Main Authors: Xie, Li, Gazin, Claude, Park, Sung Mi, Zhu, Lihua J., Debily, Marie-anne, Kittler, Ellen L. W., Zapp, Maria L., Lapointe, David, Gobeil, Stephane, Virbasius, Ching-Man, Green, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527276/
https://ncbi.nlm.nih.gov/pubmed/23284306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003151
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