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Sequential Phosphorylation of Smoothened Transduces Graded Hedgehog Signaling
The correct interpretation of a gradient of the morphogen Hedgehog (Hh) during development requires phosphorylation of the Hh signaling activator Smoothened (Smo); however, the molecular mechanism by which Smo transduces graded Hh signaling is not well understood. We show that regulation of the phos...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3526344/ https://ncbi.nlm.nih.gov/pubmed/21730325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001747 |
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