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In Vivo RNAi Screen Reveals Neddylation Genes as Novel Regulators of Hedgehog Signaling

Hedgehog (Hh) signaling is highly conserved in all metazoan animals and plays critical roles in many developmental processes. Dysregulation of the Hh signaling cascade has been implicated in many diseases, including cancer. Although key components of the Hh pathway have been identified, significant...

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Detalhes bibliográficos
Main Authors: Du, Juan, Zhang, Junzheng, Su, Ying, Liu, Min, Ospina, Jason K., Yang, Shengyuan, Zhu, Alan Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169580/
https://ncbi.nlm.nih.gov/pubmed/21931660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024168
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