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In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.

Hedgehog (Hh) signaling is highly conserved in all metazoan animals and plays critical roles in many developmental processes. Dysregulation of the Hh signaling cascade has been implicated in many diseases, including cancer. Although key components of the Hh pathway have been identified, significant...

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Main Authors: Juan Du, Junzheng Zhang, Ying Su, Min Liu, Jason K Ospina, Shengyuan Yang, Alan Jian Zhu
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science (PLoS) 2011-01-01
Sraith:PLoS ONE
Rochtain Ar Líne:http://europepmc.org/articles/PMC3169580?pdf=render
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