Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA

DNA methyltransferases catalyse the transfer of a methyl group from the ubiquitous cofactor S-adenosyl-L-methionine (AdoMet) onto specific target sites on DNA and play important roles in organisms from bacteria to humans. AdoMet analogs with extended propargylic side chains have been chemically prod...

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Bibliografiska uppgifter
Huvudupphovsmän: Lukinavičius, Gražvydas, Lapinaitė, Audronė, Urbanavičiūtė, Giedrė, Gerasimaitė, Rūta, Klimašauskas, Saulius
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2012
Ämnen:
Nucleic Acid Enzymes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526304/
https://ncbi.nlm.nih.gov/pubmed/23042683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks914
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