Programmable sequence-specific click-labeling of RNA using archaeal box C/D RNP methyltransferases

Biophysical and mechanistic investigation of RNA function requires site-specific incorporation of spectroscopic and chemical probes, which is difficult to achieve using current technologies. We have in vitro reconstituted a functional box C/D small ribonucleoprotein RNA 2′-O-methyltransferase (C/D R...

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Bibliografiska uppgifter
Huvudupphovsmän: Tomkuvienė, Miglė, Clouet-d’Orval, Béatrice, Černiauskas, Ignas, Weinhold, Elmar, Klimašauskas, Saulius
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2012
Ämnen:
Nucleic Acid Enzymes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413156/
https://ncbi.nlm.nih.gov/pubmed/22564896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks381
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