Archaeal fibrillarin–Nop5 heterodimer 2′-O-methylates RNA independently of the C/D guide RNP particle

Archaeal fibrillarin (aFib) is a well-characterized S-adenosyl methionine (SAM)-dependent RNA 2′-O-methyltransferase that is known to act in a large C/D ribonucleoprotein (RNP) complex together with Nop5 and L7Ae proteins and a box C/D guide RNA. In the reaction, the guide RNA serves to direct the m...

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Vydáno v:RNA
Hlavní autoři: Tomkuvienė, Miglė, Ličytė, Janina, Olendraitė, Ingrida, Liutkevičiūtė, Zita, Clouet-d'Orval, Béatrice, Klimašauskas, Saulius
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558902/
https://ncbi.nlm.nih.gov/pubmed/28576826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.059832.116
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