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Direct observation of cytosine flipping and covalent catalysis in a DNA methyltransferase
Methylation of the five position of cytosine in DNA plays important roles in epigenetic regulation in diverse organisms including humans. The transfer of methyl groups from the cofactor S-adenosyl-l-methionine is carried out by methyltransferase enzymes. Using the paradigm bacterial methyltransferas...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3089467/ https://ncbi.nlm.nih.gov/pubmed/21245034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1329 |
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