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Probing a rate-limiting step by mutational perturbation of AdoMet binding in the HhaI methyltransferase
DNA methylation plays important roles via regulation of numerous cellular mechanisms in diverse organisms, including humans. The paradigm bacterial methyltransferase (MTase) HhaI (M.HhaI) catalyzes the transfer of a methyl group from the cofactor S-adenosyl-l-methionine (AdoMet) onto the target cyto...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC546160/ https://ncbi.nlm.nih.gov/pubmed/15653631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki175 |
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