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Probing a rate-limiting step by mutational perturbation of AdoMet binding in the HhaI methyltransferase

DNA methylation plays important roles via regulation of numerous cellular mechanisms in diverse organisms, including humans. The paradigm bacterial methyltransferase (MTase) HhaI (M.HhaI) catalyzes the transfer of a methyl group from the cofactor S-adenosyl-l-methionine (AdoMet) onto the target cyto...

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Bibliografske podrobnosti
Main Authors: Merkienė, Eglė, Klimašauskas, Saulius
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC546160/
https://ncbi.nlm.nih.gov/pubmed/15653631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki175
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