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Dynamic modes of the flipped-out cytosine during HhaI methyltransferase-DNA interactions in solution.

Flipping of a nucleotide out of a B-DNA helix into the active site of an enzyme has been observed for the HhaI and HaeIII cytosine-5 methyltransferases (M.HhaI and M.HaeIII) and for numerous DNA repair enzymes. Here we studied the base flipping motions in the binary M. HhaI-DNA and the ternary M.Hha...

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Main Authors: Klimasauskas, S, Szyperski, T, Serva, S, Wüthrich, K
Formato: Artigo
Idioma:Inglês
Publicado: 1998
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170382/
https://ncbi.nlm.nih.gov/pubmed/9427765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.1.317
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