Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase

Rotation of a DNA or RNA nucleotide out of the double helix and into a protein pocket (‘base flipping’) is a mechanistic feature common to some DNA/RNA-binding proteins. Here, we report the structure of HhaI methyltransferase in complex with DNA containing a south-constrained abasic carbocyclic suga...

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Detalhes bibliográficos
Main Authors: Horton, John R., Ratner, Gary, Banavali, Nilesh K., Huang, Niu, Choi, Yongseok, Maier, Martin A., Marquez, Victor E., MacKerell, Alexander D., Cheng, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC506793/
https://ncbi.nlm.nih.gov/pubmed/15273274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh701
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