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Inhibition of tumorigenesis by a cytosine–DNA, methyltransferase, antisense oligodeoxynucleotide

This paper tests the hypothesis that cytosine DNA methyltransferase (DNA MeTase) is a candidate target for anticancer therapy. Several observations have suggested recently that hyperactivation of DNA MeTase plays a critical role in initiation and progression of cancer and that its up-regulation is a...

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Detalhes bibliográficos
Main Authors: Ramchandani, Shyam, MacLeod, A. Robert, Pinard, Marc, von Hofe, Eric, Szyf, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC19574/
https://ncbi.nlm.nih.gov/pubmed/9012845
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