Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

Obesity is associated with chronic low-grade inflammation that contributes to defects in energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 expression is increased in skeletal muscle of obese humans. SOCS3 inhibits leptin signaling in the hypothalamus and insulin sig...

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Detalhes bibliográficos
Main Authors: Jorgensen, Sebastian Beck, O’Neill, Hayley M., Sylow, Lykke, Honeyman, Jane, Hewitt, Kimberly A., Palanivel, Rengasamy, Fullerton, Morgan D., Öberg, Lisa, Balendran, Anudharan, Galic, Sandra, van der Poel, Chris, Trounce, Ian A., Lynch, Gordon S., Schertzer, Jonathan D., Steinberg, Gregory R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526029/
https://ncbi.nlm.nih.gov/pubmed/22961088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0443
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