tPA Contributes To Impaired NMDA Cerebrovasodilation After Traumatic Brain Injury Through Activation of JNK MAPK

OBJECTIVE: NMDA induced pial artery dilation (PAD) is reversed to vasoconstriction after fluid percussion brain injury (FPI). Tissue type plasminogen activator (tPA) is upregulated and the tPA antagonist, EEIIMD, prevents impaired NMDA PAD after FPI. Mitogen activated protein kinase (MAPK), a family...

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Hauptverfasser: Armstead, William M., Kiessling, J Willis, Riley, John, Cines, Douglas B., Higazi, Abd Al-Roof
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523283/
https://ncbi.nlm.nih.gov/pubmed/21756552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1179/016164110X12807570509853
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