Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

The use of adenovirus serotype 5 (Ad5) vectors in the clinical setting is severely hampered by the profound liver tropism observed after intravascular delivery coupled with the pronounced inflammatory and innate immune response elicited by these vectors. Liver transduction by circulating Ad5 virions...

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Detaylı Bibliyografya
Asıl Yazarlar: Bradshaw, Angela C., Coughlan, Lynda, Miller, Ashley M., Alba, Raul, van Rooijen, Nico, Nicklin, Stuart A., Baker, Andrew H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier Science Publishers 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520007/
https://ncbi.nlm.nih.gov/pubmed/22626939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.05.025
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