Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

The use of adenovirus serotype 5 (Ad5) vectors in the clinical setting is severely hampered by the profound liver tropism observed after intravascular delivery coupled with the pronounced inflammatory and innate immune response elicited by these vectors. Liver transduction by circulating Ad5 virions...

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Bibliographic Details
Main Authors: Bradshaw, Angela C., Coughlan, Lynda, Miller, Ashley M., Alba, Raul, van Rooijen, Nico, Nicklin, Stuart A., Baker, Andrew H.
Format: Artigo
Language:Inglês
Published: Elsevier Science Publishers 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520007/
https://ncbi.nlm.nih.gov/pubmed/22626939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.05.025
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