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Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors
A major limitation for adenoviral transduction in vivo is the profound liver tropism of adenovirus type 5 (Ad5). Recently, we demonstrated that coagulation factor X (FX) binds to Ad5-hexon protein at high affinity to mediate hepatocyte transduction after intravascular delivery. We developed novel ge...
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974579/ https://ncbi.nlm.nih.gov/pubmed/20610817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-260026 |
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