Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

A major limitation for adenoviral transduction in vivo is the profound liver tropism of adenovirus type 5 (Ad5). Recently, we demonstrated that coagulation factor X (FX) binds to Ad5-hexon protein at high affinity to mediate hepatocyte transduction after intravascular delivery. We developed novel ge...

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Detalhes bibliográficos
Main Authors: Alba, Raul, Bradshaw, Angela C., Coughlan, Lynda, Denby, Laura, McDonald, Robert A., Waddington, Simon N., Buckley, Suzanne M. K., Greig, Jenny A., Parker, Alan L., Miller, Ashley M., Wang, Hongjie, Lieber, Andre, van Rooijen, Nico, McVey, John H., Nicklin, Stuart A., Baker, Andrew H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974579/
https://ncbi.nlm.nih.gov/pubmed/20610817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-260026
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