Effect of Neutralizing Sera on Factor X-Mediated Adenovirus Serotype 5 Gene Transfer

The deployment of adenovirus serotype 5 (Ad5)-based vectors is hampered by preexisting immunity. When such vectors are delivered intravenously, hepatocyte transduction is mediated by the hexon-coagulation factor X (FX) interaction. Here, we demonstrate that human sera efficiently block FX-mediated c...

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Bibliographic Details
Main Authors: Parker, Alan L., Waddington, Simon N., Buckley, Suzanne M. K., Custers, Jerome, Havenga, Menzo J. E., van Rooijen, Nico, Goudsmit, Jaap, McVey, John H., Nicklin, Stuart A., Baker, Andrew H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612319/
https://ncbi.nlm.nih.gov/pubmed/18945780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01878-08
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