Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

Recent studies have demonstrated the importance of coagulation factor X (FX) in adenovirus (Ad) serotype 5–mediated liver transduction in vivo. FX binds to the adenovirus hexon hypervariable regions (HVRs). Here, we perform a systematic analysis of FX binding to Ad5 HVRs 5 and 7, identifying domains...

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Autores principales: Alba, Raul, Bradshaw, Angela C., Parker, Alan L., Bhella, David, Waddington, Simon N., Nicklin, Stuart A., van Rooijen, Nico, Custers, Jerome, Goudsmit, Jaap, Barouch, Dan H., McVey, John H., Baker, Andrew H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721791/
https://ncbi.nlm.nih.gov/pubmed/19429866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-208835
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