Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum

Human adenoviral serotype 5 (HAdV-5) vectors have predominantly hepatic tropism when delivered intravascularly, resulting in immune activation and toxicity. Coagulation factor X (FX) binding to HAdV-5 mediates liver transduction and provides protection from virion neutralization in mice. FX is dispe...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Lopez-Gordo, Estrella, Doszpoly, Andor, Duffy, Margaret R., Coughlan, Lynda, Bradshaw, Angela C., White, Katie M., Denby, Laura, Nicklin, Stuart A., Baker, Andrew H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446653/
https://ncbi.nlm.nih.gov/pubmed/28381574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02487-16
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